US Vice President JD Vance confirmed significant progress in negotiations with Iran, reiterating that the Trump administration's non-negotiable position is that Iran must never acquire a nuclear weapon. Iran's nuclear ambitions are directly tied to biblical prophecy, as Iran (ancient Persia) is identified in Ezekiel 38 as a key aggressor in the end-times coalition that will move against Israel. The drive toward nuclear capability by a nation that has openly declared its intent to destroy Israel aligns with prophetic warnings of a final great conflict centred on the Middle East.