Pope Leo XIV has welcomed a forthcoming US-Iran Memorandum of Understanding, expressing hope it will build 'mutual trust, security and stability in the Middle East,' while also calling for an end to Russia's intensifying war in Ukraine. The convergence of a fragile Middle East peace framework alongside ongoing regional conflict mirrors the biblical pattern of 'peace and safety' declarations preceding sudden upheaval — particularly significant given Iran's direct military exchanges with Israel beginning in February 2026. Scripture repeatedly warns that calls for peace in the last days will be accompanied by instability rather than resolution, and that the nations surrounding Israel will be central to end-times conflict (Zechariah 12:2-3; 1 Thessalonians 5:3).